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Mucosis wins Wellcome Trust award and backing from current investors

20 January 2016 10:51
By Tornado Staff

Dutch needle-free vaccines developer Mucosis has secured a €3.7 million translational fund award from the Wellcome Trust to progress its intranasal respiratory syncytial virus (RSV) vaccine, SynGEM, into phase I and IIa human clinical trials. The company also secured €2 million additional equity financing from its current investors. These funds will enable it to complete GMP manufacturing, and to advance the investigational medicinal product dossier (IMPD) submission materials for clinical trial approval in 2016.

Mucosis uses its technology platform to develop next-generation needle-free human vaccines for infectious diseases. The patient-friendly vaccines can be delivered via the nose or mouth to evoke a more natural immune response with a broader base of protection. The company is developing multiple programs for its clinical-stage Mimopath platform vaccine technology for several routes of administration including those that provide additional mucosal protection, where over 90% of pathogens enter the human body.

Mucosis’s lead product SynGEM is a stabilized recombinant vaccine delivered intranasally to prevent respiratory syncytial virus (RSV) infection. It will enter human proof-of-concept studies in 2016. The trials will be led by RSV expert Professor Peter Openshaw and Dr. Christopher Chiu of the National Heart & Lung Institute, Imperial College London.

The company has also developed PneuGEM, a vaccine to prevent diseases caused by pneumococcal bacteria, and FluGEM, a vaccine against influenza which served as a successful proof of concept for the Mimopath platform in human clinical testing.

Mucosis has raised over €20 million in funding, with key investment partners including MedSciences, BioGeneration, NOM and Utrecht Holdings.

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